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The creation of the Wild Roses was initially part of a Cardassian project to create human agents. By hand, Dr. Murrow created a series of human augments designed to be stronger, smarter, and able to integrate into human society. Because he was afraid of his creations turning on him, Dr. Murrow detached himself from their upbringing, referring to them only by their order of creation. (USS Baldwin: "Drift off to Dream", "Departure").
Around 2365, one of the sisters, Number Six, escaped into Federation Territory and debriefed Starfleet of the project. She was soon accepted into Starfleet Academy and eventually took the name Roslyn.
In 2374, The Dominion controlled Cardassian government kidnapped Roslyn. The USS Baldwin was assigned to recover Roslyn and arrest Dr. Murrow. The youngest of the group, Number Seven, would assist and subsequently join the Baldwin crew, taking the name. Bridget (USS Baldwin: "The Find")
The remaining five sisters would steal a Jem'Hadar fighter and settle in a system in sector 520, away from the battle. Along the way, they would pick up a Starfleet fighter pilot, Johnathan Bucyrus, who would eventually name them Jessica, Amanda, Michelle, Katie, and Valerie.