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The University of Makropyrios (sometimes just referred to as the Makropyrios) was the largest university in the Federation, at least in the 23rd century. The university had two million students. (TOS novel: The Entropy Effect)

Spock and Emanuel Tagore met at the Makropyrios. (TOS novel: The Final Reflection)

At least in the 23rd century, the Vulcan Science Academy was somehow affiliated with the Makropyrios. (Star Trek II Biographies)

Kowalczyk's Syndrome was identified by Maria Kowalczyk at the University of Makropyrios in 2282. (Star Trek: Shadowstar Station: "Through the Looking Glass")

Dr. Maria Benteen, a professor of diplomatic psychology at the Makrypyrios, took a two-year sabbatical from the university after her husband was killed during a classified mission for Starfleet in 2289. Her daughter, Gretchen, was only ten years old at the time. (Star Trek: Avenger: "Nearly a Valediction")

In 2301, Pamela Desjardins received her doctorate in genetics from the Makropyrios. (Star Trek: Avenger)

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