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The University of Makropyrios (sometimes just referred to as the Makropyrios) was the largest university in the Federation, at least in the 23rd century. The university had two million students. (TOS novel: The Entropy Effect)
- At least in the 23rd century, the Vulcan Science Academy was somehow affiliated with the Makropyrios. (Star Trek II Biographies)
Dr. Maria Benteen, a professor of diplomatic psychology at the Makrypyrios, took a two-year sabbatical from the university after her husband was killed during a classified mission for Starfleet in 2289. Her daughter, Gretchen, was only ten years old at the time. (Star Trek: Avenger: "Nearly a Valediction")