The USS Yukon (NCC-74602) was a Federation Danube-class runabout in service to Starfleet in the late 24th century.

In 2372, the Yukon was assigned to Deep Space 9. (DS9: "Sons of Mogh")

In 2373, it was used by a Changeling posing as Doctor Julian Bashir in an attempt to destroy the Bajoran star. The attempt was thwarted by the USS Defiant, though the runabout was destroyed. (DS9: "By Inferno's Light")

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