The USS Syracuse (NCC-60503) was a Nebula-class starship in service with Starfleet in the late 24th century. As of 2376, the Syracuse was under the command of Captain Raymond Alverez. Lieutenant Commander Wesley Crusher served as main science officer aboard the Syracuse. The Syracuse was armed with transphasic torpedoes and quantum phasers, along with a new XJ-255 sensor network. The Syracuse, in 2376, searched for the missing SS Seattle, which had been destroyed by a Tholian warship. A Starfleet tactical wing rendezvoused with the Syracuse and engaged the Tholian ship, destroying it.
The Syracuse was sent yet again on a dangerous mission. The Syracuse has just recently been refitted at Starbase 1 over Earth and Starfleet Command has sent the Syrcause, along with the USS Kirov and USS French. The fleet of about seventeen starships entered a nebula near the Bajor system bringing important supplies and fifteen Reman starships attacked the fleet. However, the fleet was barely able to hold off the ships. None of the ships were destroyed in the convoy; the Reman fleet suffered a total loss. (Star Trek: Syracuse eBook series)