The USS Southern Cross (NCC-1886) was an Avenger-class heavy frigate active in the 23rd century. (Starfleet International: Scott A. Akers, et al., Master Genealogy: Starfleet Region 11, Region 11 STARFLEET History)

Southern Cross was commanded by Captain R. J. Mitchell from 2283 to 2285, then Captain (later Rear Admiral) Jennifer Yates from 2285 to 2304.

Southern Cross was deployed to the Starfleet Eleventh Fleet for much of its operational lifetime, part of it as the fleet flagship.

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