USS Southampton was a Federation Starfleet ship, of unrevealed class, active in the mid-23rd century. (Expanding the Oecumene, "The Crash")
Southampton's mission profile was patrolling Sector Zero between the Sol and Alpha Centauri systems. Spock was assigned to the ship following his graduation from Starfleet Academy.
The ship was small and didn't have its own shuttlecraft.
The executive officer of the Southampton was Lieutenant Andreas Lysacek.