The USS Scorpio (NCC-1590) was an Taurus-class heavy cruiser that was service with the Federation Starfleet during the 23rd century. (Ship Recognition Manual, Volume 4: Starships of the Original Series Era)

In 2250, the Scorpio dealt a major defeat to the Orion pirate forces of Tigellus Shargin.

In 2253, the ship was discovered derelict with its crew missing. It was later believed to have been due to an Excalbian experiment.

In 2254, the ship returned to service under Captain Thomas Dubar and undertook two five-year missions.

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