The USS San Martin (NCC-4412) was a Larson-class destroyer on active duty in Starfleet for much of the 23rd century. (FASA RPG: Federation Ship Recognition Manual)

The San Martin was one of the starships that served as backup to USS Avenger during a patrol along the Klingon border in April, 2288. (Star Trek: Avenger: "Border Skirmish")

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