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The USS Rubicon (NCC-72926) was a Federation Danube-class runabout in service to Starfleet in the late 24th century.
The Rubicon was one of the first five Danube runabouts to enter service with Starfleet. (Ship Recognition Manual, Volume 1: The Ships of Starfleet)
In 2371, the Rubicon was assigned to Deep Space 9 to replace the destroyed USS Mekong. (DS9: "Family Business")