USS Perseus (NCC-544) was a Saladin-class destroyer — of the Cochise-subclass — on active duty in Starfleet during at least the 23rd century. (Star Fleet Technical Manual)

Stephen Penik served as a sciences officer on Perseus in the mid-2270s. (Star Trek: Avenger: "Star Survey")

Perseus participated in the defeat of the Darnath in the Voranis system in June 2299. (Star Trek: Avenger: "The Road Goes Ever On")

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