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The USS Orinoco (NCC-72905) was a Federation Danube-class runabout in service to Starfleet in the late 24th century.
The Orinoco was one of the first five Danube runabouts to enter service with Starfleet. (Ship Recognition Manual, Volume 1: The Ships of Starfleet)
In 2369, the Orinoco was assigned to Deep Space 9 to replace the destroyed USS Yangtzee Kiang. (DS9: "The Siege")
In 2372, the Orinoco was destroyed by the True Way terrorist group. (DS9: "Our Man Bashir")