The USS Miskatonic was a Danube-class runabout in service during the late 24th century. The Miskatonic was often used for scientific research, and at one point in time operated under the auspices of the Jackson Center for Archaeology.

In 2385, the Miskatonic was used as a testbed for a new form of inversion drive. (Star Trek: Pendragon: "Applied Physics")

Named for H.P. Lovecraft's fictional river.

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