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The Mekong was one of the first five Danube runabouts to enter service with Starfleet. (Ship Recognition Manual, Volume 1: The Ships of Starfleet)
In 2371, the Mekong was captured and stored on a Romulan warbird that was part of the Tal Shiar-Obsidian Order fleet that took part in the Battle of the Omarion Nebula, it was destroyed along with the warbird during the battle. (DS9: "The Die is Cast"; Ship Recognition Manual, Volume 1: The Ships of Starfleet)
|USS Avon - USS Cedar - USS Columbia - USS Danube - USS Des Plaines - USS Ganges - USS Hudson - USS Hurunui - USS Iroh - USS Kishwaukee - USS Lagan - USS Little Big Horn - USS Marmaton - USS Mekong - USS Miskatonic - USS Murray - USS Neosho - USS Ninnescah - USS Orinoco - USS Rhine - USS Rio Grande - USS Rubicon - USS Severn - USS Shannon - USS Shenandoah - USS Tigris (I) - USS Tigris (II) - USS Verdigris - USS Volga - USS Waimakariri - USS Willamette - USS Wye - USS Yangtzee Kiang - USS Yukon|