USS Maryland (NCC-45109) was a Renaissance-class cruiser on active duty in Starfleet during the 24th century. (Star Trek Encyclopedia)
The Maryland was one of several ships that went missing in the Gamma Quadrant prior to 2373 that were believed to have been destroyed by the Dominion. (DS9: "In Purgatory's Shadow"; Ship Recognition Manual, Volume 1: The Ships of Starfleet)
The vessel was named after the state of Maryland, in the United States of America on Earth. It may also have been named after previous wet-navy ships and spacecraft named Maryland.