The USS Lumbee was a Federation starship active in the early 25th century.

Jennifer van der Putte was the Lumbee's chief engineer in 2410. During the Iconian War that year, the Lumbee was part of the Third Fleet, which was completely annihilated in a Herald attack, without even getting off a distress signal. (Bait and Switch: "All In")

The Lumbee appears to be named for North Carolina's Lumbee tribe, suggesting it may be intended as a Cheyenne-class or Dakota-class starship.