USS Imbrium (NCC-4462) was a Larson-class destroyer on active duty in Starfleet during the mid- to late-23rd century. She was commissioned in March, 2253. (FASA RPG: Federation Ship Recognition Manual)

Imbrium diverted to Earth Outpost 4 as part of the Starfleet force responding to the crisis in October, 2287. (Star Trek: Avenger: "By Honor Bound")

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