The USS Determination (NX-78236) was an experimental Federation escort starship in Starfleet service during 24th century. She was the first of her class.

The Determination was one of two hybrid Starfleet-Kaartali Star Navy starships in service in the 2370s, assigned to the USS Cantabrian-A as a support craft.

Features included a standard type 7-A warp drive and Kaartali transphasic torpedo launchers. Standard crew compliment was approximately 40. The ship was also able of atmospheric entry and planetary landing. (Star Trek: The Cantabrian Expeditions: "Howl")

In 2376, on a mission to the New Bolarus colony, the Determination was attacked by the Vendoth and forced to the colony's surface. After repairs were made and the colonists were saved, the Determination successfully gained low orbit around the colony and attracted the Cantabrian's attention by detonating photon torpedoes. The Cantabrian managed to save the Determination from destruction. (Star Trek: The Cantabrian Expeditions: "Howl")

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