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The Denali was a heavy participant in the Dominion War as part of the 856th Tactical Wing, Starfleet Eighth Fleet, spending the first two-thirds of the war defending Andoria and later often fought along the front lines. During the early part of 2374, the Denali was commanded by Captain Amanda Coe. (LUG RPG: The Dominion War Sourcebook: The Fires of Armageddon)