USS Defiance (NCC-1717) was a Constitution-class heavy cruiser on active duty in Starfleet during at least the late 23rd century. (Star Fleet Technical Manual)

The Defiance may exist in an alternate timeline from one where the similarly-named USS Defiant exists.

In the 2280s, Defiance was deployed to the Starfleet Fourth Fleet. Her commanding officer for many years was Captain (later Admiral) Robert Lerman. (Starfleet International: USS Defiance)

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