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USS Defiance (NCC-1717) was a Constitution-class heavy cruiser on active duty in Starfleet during at least the late 23rd century. (Star Fleet Technical Manual)
- The Defiance may exist in an alternate timeline from one where the similarly-named USS Defiant exists.
In the 2280s, Defiance was deployed to the Starfleet Fourth Fleet. Her commanding officer for many years was Captain (later Admiral) Robert Lerman. (Starfleet International: USS Defiance)