The USS Defender (NCC-74208) was a Defiant-class Federation starship in service in the late 24th Century. In 2374 Captain Jonozia Lex was given temporary command of the Defender during the mission to the recapture of the USS Prometheus from Romulan hijackers. (VOY: "Message in a Bottle", Star Trek: The Adventures of Argus: "Messages From Home"")
Around the same time this ship was also uncovered on Earth, having crashed there in the 21st Century. (Star Trek: The Adventures of Argus: "Messages From Home", "Nuclear Time")
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