USS Constellation II (NCC-1728) was a Constitution-class heavy cruiser — part of the Endeavour-subclass — in service during the late 23rd century. (Star Fleet Technical Manual) It was intended to replace USS Constellation.

Constellation II was commissioned in February 2275.

In mid-2276, Stephen Penik was looking forward to a transfer to the Constellation II. (Star Trek: Avenger: "Star Survey")

Captain Aya Nakajima was commanding officer of Constellation II ca. 2288. (Dockyard Review 2:1 (January 2290). Nakajima, Aya. "Comment: The Enterprise (II) Class.")

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