USS Constellation II (NCC-1728) was a Constitution-class heavy cruiser — part of the Endeavour-subclass — in service during the late 23rd century. (Star Fleet Technical Manual) It was intended to replace USS Constellation.

Constellation II was commissioned in February 2275.

In mid-2276, Stephen Penik was looking forward to a transfer to the Constellation II. (Star Trek: Avenger: "Star Survey")

Lieutenant Commander Angelica McKnight was stationed on the Constellation II in the late 2270's as communications officer. (The Lexington Adventures)

Captain Aya Nakajima was commanding officer of Constellation II ca. 2288. (Dockyard Review 2:1 (January 2290). Nakajima, Aya. "Comment: The Enterprise (II) Class.")

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