The USS Cartwright (NCC-42953) was an Excelsior-class starship. In 2360, Captain Sydney Caldwell was the commanding officer when the Cartwright disappeared with all hands during the Federation-Tzenkethi War. (Star Trek: The Cantabrian Expeditions: "Breaking Benjamin", "Better the Devil You Know", "Bitter Sweet")

Starfleet Command assumed the Cartwright was destroyed with all hands.

The USS Cartwright was named after Silvia Cartwright, Governor-General of New Zealand from 2001 until 2006.

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