USS Callisto (NCC-80109) was a Luna-class exploration cruiser on active duty in Starfleet during the late 24th century. (Star Trek: Titan novel: Sword of Damocles)
The Callisto was launched in 2379 under the command of Captain Alyson Foxton. (Star Trek: The Adventures of Argus)
In 2410, the Callisto was on an exploration mission in the Delta Quadrant 30,000 light years from the Sol System. The Callisto was destroyed either by the Voth or the Vaadwar. (Star Trek Online mission: Revelations)
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