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The USS Cairo (NCC-69124) was a Federation starship that saw service during the 24th century. In 2374, it was commanded by Captain Leslie Wong when the vessel was destroyed by the Jem'Hadar whilst on patrol of the Romulan Neutral Zone. (DS9: "In the Pale Moonlight"; The Dominion War Sourcebook: The Fires of Armageddon)
- This ship is specifically identified in The Dominion War Sourcebook: The Fires of Armageddon, which possibly means that by 2374 the Excelsior-class USS Cairo (NCC-42136) had been decommissioned and replaced by this vessel.