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The USS Apache (NCC-51821) was a Cheyenne-class exploration cruiser active in the mid-24th century.

In 2354, during the Federation-Tholian War, Station Salem-One (aka Shadowstar Station) was the site of a Tholian attack. Among the Federation starships present at the station was the Apache (USS Cheyenne Operations Manual; Star Trek: Shadowstar Station: "Blindspot").

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