The USS Alliance (NCC-1849) was a Constitution-class heavy cruiser — of the Enterprise (II)-subclass — on active duty in Starfleet during at least the 23rd century. Alliance was commissioned in early 2291. (Ships of the Star Fleet, vol. 1 [revised])

Alliance was scheduled to rendezvous with USS Avenger at the end of January 2293 to transfer Jonathan Lane to his new duty assignment. However, when Alliance was diverted, Lane was given the option to remain with Avenger. (Star Trek: Avenger: "The Essential Process")

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