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In 2377, the Borg Collective managed to create a transwarp gate between a transphasic nebula in the Delta Quadrant and a similar nebula in the Regula Badlands region of the Beta Quadrant. The creation of these corridors allowed the Borg to attack and assimilate several Federation and Romulan colonies without encountering significant resistance.
This same conduit was later utilized by Starfleet to dispatch a fleet of starships, led by the USS Enterprise-E, into the Delta Quadrant to launch an attack on the Collective. (TNG computer game: Armada II)