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The Trajan Nebula is a gaseous cloud of particles and minerals located in the Oralian sector. The particles and minerals found in the nebula can be captured in a Starfleet vessel's Bussard collectors, or any equivalent apparatus, and later synthesized to generate power. This technique has been used effective by the So'ja for centuries. (Star Trek: Pioneer)
- The USS Pioneer, under the command of Captain Benjamin Kelsoe, encountered the Romulan Warbird IRW Thrai in the Trajan Nebula. ("Unresolved Matters")
- In 2381 The USS Milburn and the USS Tacitus claimed to have spotted Tyson Calok around the Trajan Nebula.
- The USS Regal was attack by the So'ja warship CWS Kal'fei near the Trajan Nebula, effectively starting the Coalition War. ("The Hornet's Nest")