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In 2368, the USS Chevalier tested a plasma dissipater in the nebula. The plasma dissipater, along with the runabout it was integrated with, were stolen by a group known as the "Brigade." (Dark Territory: "The Crucible")
There were reports of Jem'Hadar activity in the nebula in 2373. Since the Klingon High Council issued orders to avoid unnecessary combat, General Martok ordered his vessel, the IKS Rotarran, to go around the nebula while searching for the IKS B'Moth. His crew was displeased with the decision. (DS9: "Soldiers of the Empire")
Also in 2374, the USS Lambda Paz investigated intelligence suggesting a Jem'Hadar breeding facility was on a planetoid in the nebula. Initial investigation suggested this intelligence was authentic. Later investigations revealed that no breeding facility on the planetoid, as the Dominion set a plan in motion to lure Starfleet into an ambush in Sector 21607 after suffering heavy losses at Torros III. The resulting battle dealt the Federation Alliance a crippling blow. (Star Trek: Lambda Paz,"Revenge a Dish Best Served Cold")