Task Force 72 was a Starfleet task force extant in the late 24th century. It was part of the Starfleet Seventh Fleet.

In 2377-78, Rear Admiral Robert E. Vosseller IV was Task Force 72's commanding officer aboard the flagship USS Challenger (a Galaxy-class large exploration cruiser). Task Force 72 was deployed on a mission of coreward exploration and homeported at Starbase 185. (Ships of the Star Fleet, Vol. 4: Star Fleet Operating Forces. )

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