Task Force 45 was a Starfleet task force extant in the late 24th century. It was part of the Starfleet Fourth Fleet.

In 2377-78, Rear Admiral Renée Bunford was Task Force 45's commanding officer aboard the flagship USS Athena (a Nebula-class light cruiser commanded by Fleet Captain Goksel Tobias). Task Force 45, deployed on patrol missions, was then homeported at K'Ehleyr Station. (Ships of the Star Fleet, Vol. 4: Star Fleet Operating Forces. )

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