Septimus III was a planet in the Cardassian Union.

In 2375, the Klingons invaded the planet and slaughtered the Eleventh Order, over 500,000 Cardassians; the Dominion had tasked a grand total of three Galor-class vessels to defend the planet against fifteen divisions of Klingons. (DS9: "Strange Bedfellows", Star Trek: Sigils and Unions--The Thirteenth Order)

Ecological ramifications of the assault could prove devastating in the long term: a Cardassian eyewitness, Gul Tayben Berat of the Sherouk, described the Klingons as having "nearly blasted the atmosphere off the planet." Radiation levels in the area of the orbital assault were lethal in the immediate aftermath, and the quantum torpedo bombardment and resulting volcanism and seismic activity caused an extremely severe "nuclear" winter that preliminary estimates suggested would make the planet inhospitable to higher life for thousands of years. (Star Trek: Sigils and Unions--The Thirteenth Order, "Those Who Remain")

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