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Psionic energy is generally associated with various mental processes such as Telepathy.

Gary Mitchell experienced a marked increase in psionic abilities when the Enterprise neared the Galactic barrier (TOS: "Where No Man Has Gone Before").

Species with psionic abilities included Betazoids who were able to telepathically communicate within their own species with relative ease. A non-corporeal being known as Onaya had psionic abilities (DS9: "The Muse"). Vulcan mind melds were a form of touch telepathy (TOS: "Dagger of the Mind").

Calafans had psionic abilities, but only in conjunction with their dream states (In Between Days: Reversal, Temper). Dreams could be amplified using a naturally-occurring substance known as callidium, which was present in the extremity skin of full-blooded Calafans and known as calloo (In Between Days: Fortune).

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