A positronic brain is an advanced computer or computer-like device, operating like the humanoid brain, with the ability to possibly encourage artificial sentience. Dr. Noonien Soong was the first known human to create this device and used it on several of his android creations, including Data, Lore, B-4 and Juliana Soong.

The extremely complex brain operates through an artificial neural network. Soong installed at least seven positronic brains into his androids, but only the aforementioned creations were stable.

In 2366, Data created a positronic brain for his "offspring", Lal, but the positronic net failed. (TNG: "The Offspring")

Isaac Asimov created the term "positronic brain" in his works.

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