Nathan Littlejohn was an Earth Starfleet officer active in the 22nd century. (USS Cheyenne Operations Manual)
During the Earth-Romulan War, Littlejohn was commanding officer of the starship Essex. He fought with distinction during the Third Battle of Gamma Hydra.
- It has not been confirmed that the Essex commanded by Littlejohn was a Daedalus-class starship that would be contemporary with the war.
In the 24th century, a Cheyenne-class exploration cruiser would be named after him.
- It is not known if he was related to Lydia Littlejohn, then-Prime Minister of United Earth.