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During 2372, the USS Cantabrian had several run-ins with Myhr'an battle cruisers. After the Cantabrian's launch, they responded to a distress call from the USS Koru, under attack by a Myhr'an battle cruiser. After rescuing the Koru survivors, the Cantabrian made a hasty exit. (Star Trek: The Cantabrian Expeditions: "Catalyst, Part One")
The Cantabrian faced three Myhr'an battle cruisers when investigating the disappearance of Starbase Expanse 3 personnel. Again, they retreated. (Star Trek: The Cantabrian Expeditions: "Catalyst, Part One")
Several Myhr'an battle cruisers accompanied the Myhr'an super battle cruiser. These battle cruisers suffered auto self-destruction sequences when their crews' link with an alien force controlling them was shut off. (Star Trek: The Cantabrian Expeditions: "Catalyst, Part Two")
The Cantabrian and USS Aotearoa faced three Myhr'an battle cruisers in the Rhinessa system while trying to rescue survivors in a Myhr'an internment camp. (Star Trek: The Cantabrian Expeditions: "Two Hit, One Stone")
In defending Canaileus Prime from Myhr'an invasion, the Cantabrian successfully fought off a Myhr'an battle cruiser with the assistance of the FNN ship, D'Audney. FNN reporter Kevin Alton rammed the D'Aubrey into the Myhr'an battle cruiser, destroying it. (Star Trek: The Cantabrian Expeditions: "Oh, What a Lovely War")