The Mutara Nebula was a nebula located in the Mutara sector.

In 2228, the Federation and Klingons engaged in a battle near the nebula resulting in the destruction of the USS Bastion and at least five Klingon cruisers. (Ship Recognition Manual, Volume 4: Starships of the Original Series Era)

In 2285, the USS Enterprise engaged the USS Reliant in a fierce battle in the nebula, which resulted in the destruction of the Reliant. (Star Trek II: The Wrath of Khan)

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