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In that year, Manheim opened a dimensional window on Vandor IV. The repercussions were felt thousands of light years away, with time loops and other phenomenon occurring. Data sealed the original window, stopping the effect. (TNG: "We'll Always Have Paris")
Shortly after that incident, the USS Scandalon, under the command of Steven Tecklenberg, was assigned to investigate Dr. Manheim's lab complex and the magnitude of the Manheim effect. Lt. Timothy Sinclair encountered several alternate versions of himself while on the mission. (Star Trek: Pendragon: "Reflections")
The measure of how much time is affected by disturbances and distortions is measured against the Manheim-Hudec scale, much like earthquakes are measured against the Richter magnitude scale. (Star Trek: The Prospect Chronicles; Star Trek: The Cantabrian Expeditions)