The Kel-j'na Region is an area of space in the Alpha Quadrant of the Milky Way galaxy, approximately 30,000 light years distant from the United Federation of Planets and 32,000 light years from the galactic core. Species indigenous to the area include the Kel-j'na, Fashod, Naitr'm, Zeparans, and the Levalum Clan. It is also the location of the planet Hel'yra.

In 2374, the Federation began sending starships to the Kel-j'na Region through the Tartarus Wormhole. Within two years, fifty Federation colonies had been established in the area, and several worlds were applying for Federation membership. In 2376, Starfleet sent the Oceana-class USS Chamberlain to survey and investigate Hel'yra, leading to discoveries regarding the Ancient Progenitors. (Star Trek: Dark Horizon)

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