The Kalium Galaxy is a galaxy located billions of lightyears from the Milky Way Galaxy.

The Kalium galaxy was the furthest galaxy visible from Earth. The USS Dragon-A was the first Federation vessel to visit this galaxy after been accidentally transported there. (Star Trek: Dragon: "The New Frontier")

Although sensor data was lost when the Dragon was destroyed upon returning to Earth, science officers aboard the Dragon gained phenomenal understanding of the life span of a galaxy by comparing visual records of the Kalium Galaxy from Earth, billions of years old due to the speed of light, with current sensor data from the galaxy. (Star Trek: Dragon)

A regional power in the Kalium galaxy was the Vendoth. The Vendoth would be the first species native to the Kalium galaxy to travel to the Milky Way. (Star Trek: Unity (crossover))

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