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Legendary even in her own time, Enterprise (NX-01) was the prototype NX-class starship, the first human vessel capable of reaching warp five, and the flagship of the United Earth Starfleet. Launched in 2151 under the command of Captain Jonathan Archer, Enterprise's exploits established Earth as an interstellar power in the mid-22nd century and forever altered the political face of the Alpha and Beta Quadrants, helping to pave the way for the birth of the United Federation of Planets.
Among Enterprise's accomplishments during her decade of service were many successful first contacts, most notably those with the Andorians, Axanar, Suliban, Tholians and Xindi. (ENT: "The Andorian Incident", "Fight or Flight", "Broken Bow", "Future Tense", "The Xindi")
The latter contact involved a long-term mission into the Delphic Expanse, lasting from 2153 to 2154. (ENT: "The Expanse", "Zero Hour", et. al) Enterprise also became involved in the so-called Temporal Cold War between various factions from future eras, resulting in numerous alternate timelines, which were "reset" in 2154 when the War was "wiped from history." (ENT: "Cold Front", "Storm Front, Part II", et. al)
Afterwards, Enterprise became a pivotal element in galactic politics, instigating the Vulcan Reformation, taking the first steps toward uniting Earth with Vulcan, Andoria and Tellar against the Romulan Star Empire, and helping save the Klingon Empire from a mutagenic disease. She also fought threats closer to home, such as Dr. Arik Soong and his Augments, and the radical Terra Prime group. (ENT: "Awakening", "United", "Affliction", "Borderland", "Terra Prime", et. al)
Having (presumably) fought in the Earth-Romulan War, Enterprise remained under Captain Archer's command until 2161, when she returned home for the founding of the United Federation of Planets. (ENT: "These Are the Voyages")
The Enterprise was still in comission as of 2256, being the oldest vessel in Starfleet to retain the honor (similar to the sailing vessel USS Constitution of old earth). In December of 2256, after a decade of restoration work, the Enterprise was officially fully opened at Memory Alpha as the centerpeice of an exhibit highlighting the 100 year anniversary of the Earth-Romulan War (Star Trek: The Four Years War, Book 2).
|Atlantis - Challenger - Cochrane - Columbia - Daedalus - Dauntless - Endeavour - Enterprise - Liberty - San'rath - Saratoga - Zefram Cochrane|
|Star Trek: Poseidon: Atlantis - Challenger - Discovery - Poseidon|
|Starfleet: The First Era: ESS Meridian - ESS Phoenix - ESS Shenandoah - ESS Trope - ESS Yorktown|
|USS Baldwin: Atlantis - Discovery|
|Star Trek: Remington: Endeavour|
|Mirror universe: ISS Enterprise - ISS Avenger|