Deep Space 6 was a Federation Starbase in operation in the late 24th century. It was located near Zakdorn and the Romulan border on the core ward edge of Federation space. In 2374 the starbase was commanded by Admiral Rothschild. (Star Trek: Star Charts, Star Trek: The Adventures of Argus: "Messages From Home")

In 2374, the starbase was the destination of a supply convoy protected by the USS Argus. Shortly after the Argus' arrival, the Starbase responded to the hijacking of the USS Prometheus by dispatching the USS Spector, USS Alexander and USS Defender. (Star Trek: The Adventures of Argus: "Messages From Home")

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