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- It existed as early as the 2280s, as Admiral Cartwright was Starfleet's liaison to the Institute at that time. (Star Trek: Excelsior novel: Forged in Fire)
By the mid-24th century, the Institute maintained a large annex on Galor IV which was dedicated to researching technological advancements in the fields of cybernetics and experimental propulsion systems. (TNG: "The Offspring")