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Sanctuary Districts were located in various cities in the US by 2024. The famous Bell Riots occurred in San Francisco when the Californian governor ordered troops to take the facility back by force, resulting in hundreds of deaths. (DS9: "Past Tense, Part I", "Past Tense, Part II")
- Christopher Pike was born in Mojave, California in 2220. (EV comic: "The Flat, Gold Forever")
- Charlotte Smith lived in Los Angeles, California for most of her life. (Star Trek: Lexington (fan film series))
- William Telfer was born in Encino, California to Ryan and Julia Telfer in 2352. (Star Trek: Voyager - Dark Realm)