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The Andromeda Galaxy is the closest spiral galaxy to the Milky Way and part of the Local Group. From its closest point to the Alpha Quadrant it is approximately 2.5 million light years away. Intelligent lifeforms in Andromeda include the Kelvans, the Saer'nar and the Archein. (TOS: "By Any Other Name"; On a Knife Edge, Star Trek: Odyssey)
In 2384, Section 31 sent Theseus, aboard the USS Phoenix-X, to the Andromeda Galaxy using an altered-transwarp engine, in order to gain the Kelvans as Section 31 allies. Upon entering the Galaxy, the Phoenix-X was forced out of transwarp due to abnormally high radiation levels. The Kelvans chose to keep their dominant values and not accept Theseus' offer. Instead, Theseus found the Kelvans to be developing Omega molecules. Theseus then acquired a group of these molecules for himself, suspending them within an Andromedan android's abdomen using Kelvan technology. The Phoenix-X returned home to the Milky Way safely and had the adjustments to their engine dismantled. (Star Trek: Phoenix-X: "Forbidden Crossing, Part III")