The American Continent Institute was a scientific and educational institute based on Earth.

In the 2120s, the Institute sponsored a survey of Wolf-catalogue stars near the Sol system. This survey expedition discovered reserves of pergium and topaline on the fifth planet of Wolf 359. (Star Trek: Shadowstar Station)

The Gagarin-class USS Leonov, after its withdrawal from frontline service, served for many years with a succession of civilian scientific and academic institutions, including the United Federation of Planets Institute of Science (as SS Fermi), the University of Mars, Port Lowell (as SS Barsoom), and the American Continent Institute (as SS Columbia), which was lost in 2236. (The Starfleet Museum: Gagarin-Class Light Cruisers)

The Institute launched the ill-fated SS Columbia expedition that crashed on Talos IV in ca. 2236. (TOS: "The Cage")

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