- It has not yet been established how the continent's individual nation-states developed from having an Organisation of Africa Unity (1963-2002) and an African Union, established in 2002, to the Confederation.
In 2322, 2327 and 2335 respectively, Marie Bourget, Alexandra de Groot and Geordi LaForge were born in the African Confederation. (Star Trek: The Cantabrian Expeditions; Star Trek: Shabonee; TNG: "The Next Phase")
- It remains unclear if this entity is the same as the United States of Africa, where Nyota Uhura was suggested to have been born -- or if there are two political alliances on the continent. (TAS: "The Counter-Clock Incident")
By the late 24th century, one of the longest maglev routes on Earth was in the Confederation, down Africa's Atlantic coast from Casablanca to Cape Town. (Last Unicorn Games RPG: The Cadet's Guide to Sector 001)