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|22nd century - 23rd century - 24th century|
- The USS Enterprise diverts to Talos IV after receiving a distress call from the SS Columbia. (TOS: "The Cage")
- In an alternate timeline, Christopher Pike’s Enterprise is destroyed by a Doomsday Machine that had come back in time from 2373, causing a distortion in the recorded timeline. The Doomsday Machine begins duplicating itself and spreading destruction across the galaxy. Starfleet Command rescinds all standing orders regarding exploratory missions. Code named Operation: Ragnarok, the seemingly endless series of losing battles become colloquially known as "The Doomsday War." (Star Trek: Phase II: "In Harm's Way")
- The USS Minervon is hijacked en route from Vulcan. The hijackers were believed to be members of the radical Sh'ak'atar religious sect. A failed rescue attempt by Starfleet resulted in the hostages being marooned for over a year. The Minervon Incident is used as a case study in the Academy survival course. (Star Trek: SFI)
- The starships Exeter and John F. Kennedy helped establish the colony on Gamma Hydra IV. (Orion Press: The Mindsweeper)
- Michael Sinclair is born in Ohio on Earth. (Star Trek: USS Hathaway)
- David Stein is born on Earth. (Tales of the Seventh Fleet)