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|2070s 2080s 2090s 2110s 2120s 2130s 2140s|
|21st century - 22nd century - 23rd century|
- A pathogenic illness known as Martian fever ravages the Martian Colonies. (Star Fleet Medical Reference Manual)
- Arcturus, a Bonaventure-class explorer, was retasked as a commercial carrier (thus, it changed designation from “UNSS” to “SS”) for use by scientific expeditions. Its modular design made it ideal for such tasks ("The USS Arcturus in History")